Publications

Osei-Sarfo K, Gudas LJ.  2014.  Retinoic acid suppresses the canonical Wnt signaling pathway in embryonic stem cells and activates the noncanonical Wnt signaling pathway.. Stem Cells. 32(8):2061-71.

Orfali N, McKenna SL, Cahill MR, Gudas LJ, Mongan NP.  2014.  Retinoid receptor signaling and autophagy in acute promyelocytic leukemia.. Exp Cell Res. 324(1):1-12.

Gudas LJ, Fu L, Minton DR, Mongan NP, Nanus DM.  2014.  The role of HIF1α in renal cell carcinoma tumorigenesis.. J Mol Med (Berl). 92(8):825-36.

Urvalek A, Laursen KBruun, Gudas LJ.  2014.  The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes.. Subcell Biochem. 70:129-49.

Fu L, Wang G, Shevchuk MM, Nanus DM, Gudas LJ.  2013.  Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis.. Cancer Res. 73(9):2916-25.

Tang X-H, Scognamiglio T, Gudas LJ.  2013.  Basal stem cells contribute to squamous cell carcinomas in the oral cavity.. Carcinogenesis. 34(5):1158-64.

Hedblom A, Laursen KB, Miftakhova R, Sarwar M, Anagnostaki L, Bredberg A, Mongan NP, Gudas LJ, Persson JL.  2013.  CDK1 interacts with RARγ and plays an important role in treatment response of acute myeloid leukemia.. Cell Cycle. 12(8):1251-66.

Ricard MJ, Gudas LJ.  2013.  Cytochrome p450 cyp26a1 alters spinal motor neuron subtype identity in differentiating embryonic stem cells.. J Biol Chem. 288(40):28801-13.

Pérez RJ, Benoit YD, Gudas LJ.  2013.  Deletion of retinoic acid receptor β (RARβ) impairs pancreatic endocrine differentiation.. Exp Cell Res. 319(14):2196-204.

Kauffman EC, Robinson BD, Downes M, Marcinkiewicz K, Vourganti S, Scherr DS, Gudas LJ, Mongan NP.  2013.  Estrogen receptor-β expression and pharmacological targeting in bladder cancer.. Oncol Rep. 30(1):131-8.

Kopparapu PKumar, Boorjian SA, Robinson BD, Downes M, Gudas LJ, Mongan NP, Persson JL.  2013.  Expression of cyclin d1 and its association with disease characteristics in bladder cancer.. Anticancer Res. 33(12):5235-42.

Kopparapu PKumar, Boorjian SA, Robinson BD, Downes M, Gudas LJ, Mongan NP, Persson JL.  2013.  Expression of VEGF and its receptors VEGFR1/VEGFR2 is associated with invasiveness of bladder cancer.. Anticancer Res. 33(6):2381-90.

Benoit YD, Laursen KB, Witherspoon MS, Lipkin SM, Gudas LJ.  2013.  Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.. J Cell Physiol. 228(4):764-72.

Kashyap V, Ahmad S, Nilsson EM, Helczynski L, Kenna S, Persson JLiao, Gudas LJ, Mongan NP.  2013.  The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer.. Mol Oncol. 7(3):555-66.

Osei-Sarfo K, Tang X-H, Urvalek AM, Scognamiglio T, Gudas LJ.  2013.  The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC.. Carcinogenesis. 34(11):2673-81.

Benoit YD, Witherspoon MS, Laursen KB, Guezguez A, Beauséjour M, Beaulieu J-F, Lipkin SM, Gudas LJ.  2013.  Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells.. Exp Cell Res. 319(10):1463-70.

Laursen KB, Mongan NP, Zhuang Y, Ng MM, Benoit YD, Gudas LJ.  2013.  Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene.. Nucleic Acids Res. 41(13):6430-43.

Kashyap V, Laursen KB, Brenet F, Viale AJ, Scandura JM, Gudas LJ.  2013.  RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells.. J Cell Sci. 126(Pt 4):999-1008.

Gudas LJ.  2013.  Retinoids induce stem cell differentiation via epigenetic changes.. Semin Cell Dev Biol. 24(10-12):701-5.

Marcinkiewicz K, Scotland KB, Boorjian SA, Nilsson EM, Persson JLiao, Abrahamsson PAnders, Allegrucci C, Hughes IA, Gudas LJ, Mongan NP.  2012.  The androgen receptor and stem cell pathways in prostate and bladder cancers (review).. Int J Oncol. 40(1):5-12.

Gudas LJ.  2012.  Emerging roles for retinoids in regeneration and differentiation in normal and disease states.. Biochim Biophys Acta. 1821(1):213-21.

Laursen KB, Wong P-M, Gudas LJ.  2012.  Epigenetic regulation by RARα maintains ligand-independent transcriptional activity.. Nucleic Acids Res. 40(1):102-15.

Benoit YD, Lepage MB, Khalfaoui T, Tremblay E, Basora N, Carrier JC, Gudas LJ, Beaulieu J-F.  2012.  Polycomb repressive complex 2 impedes intestinal cell terminal differentiation.. J Cell Sci. 125(Pt 14):3454-63.

Kashyap V, Gudas LJ, Brenet F, Funk P, Viale A, Scandura JM.  2011.  Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid.. J Biol Chem. 286(5):3250-60.

Fu L, Wang G, Shevchuk MM, Nanus DM, Gudas LJ.  2011.  Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1α.. Cancer Res. 71(21):6848-56.