Publications

Urvalek AM, Gudas LJ.  2014.  Retinoic acid and histone deacetylases regulate epigenetic changes in embryonic stem cells.. J Biol Chem. 289(28):19519-30.

Kashyap V, Rezende NC, Scotland KB, Shaffer SM, Persson JLiao, Gudas LJ, Mongan NP.  2009.  Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs.. Stem Cells Dev. 18(7):1093-108.

Sheren-Manoff M, Shin SJ, Su D, Bok D, Rando RR, Gudas LJ.  2006.  Reduced lecithin:retinol acyltransferase expression in human breast cancer.. Int J Oncol. 29(5):1193-9.

Boorjian S, Tickoo SK, Mongan NP, Yu H, Bok D, Rando RR, Nanus DM, Scherr DS, Gudas LJ.  2004.  Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer.. Clin Cancer Res. 10(10):3429-37.

Amat R, Gudas LJ.  2011.  RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells.. J Cell Physiol. 226(2):293-8.

Kashyap V, Laursen KB, Brenet F, Viale AJ, Scandura JM, Gudas LJ.  2013.  RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells.. J Cell Sci. 126(Pt 4):999-1008.

Mongan NP, Martin KM, Gudas LJ.  2006.  The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures.. Mol Carcinog. 45(12):887-900.

Benoit YD, Lepage MB, Khalfaoui T, Tremblay E, Basora N, Carrier JC, Gudas LJ, Beaulieu J-F.  2012.  Polycomb repressive complex 2 impedes intestinal cell terminal differentiation.. J Cell Sci. 125(Pt 14):3454-63.

Laursen KB, Mongan NP, Zhuang Y, Ng MM, Benoit YD, Gudas LJ.  2013.  Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene.. Nucleic Acids Res. 41(13):6430-43.

Goldberg JS, Vargas M, Rosmarin AS, Milowsky MI, Papanicoloau N, Gudas LJ, Shelton G, Feit K, Petrylak D, Nanus DM.  2002.  Phase I trial of interferon alpha2b and liposome-encapsulated all-trans retinoic acid in the treatment of patients with advanced renal cell carcinoma.. Cancer. 95(6):1220-7.

David KA, Mongan NP, Smith C, Gudas LJ, Nanus DM.  2010.  Phase I trial of ATRA-IV and Depakote in patients with advanced solid tumor malignancies.. Cancer Biol Ther. 9(9):678-84.

Boorjian SA, Milowsky MI, Kaplan J, Albert M, Cobham MVallee, Coll DM, Mongan NP, Shelton G, Petrylak D, Gudas LJ et al..  2007.  Phase 1/2 clinical trial of interferon alpha2b and weekly liposome-encapsulated all-trans retinoic acid in patients with advanced renal cell carcinoma.. J Immunother. 30(6):655-62.

Benoit YD, Witherspoon MS, Laursen KB, Guezguez A, Beauséjour M, Beaulieu J-F, Lipkin SM, Gudas LJ.  2013.  Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells.. Exp Cell Res. 319(10):1463-70.

Del Aguila EMere, Tang X-H, Gudas LJ.  2022.  Pancreatic Ductal Adenocarcinoma: New Insights into the Actions of Vitamin A.. Oncol Res Treat.

Tang X-H, Su D, Albert M, Scognamiglio T, Gudas LJ.  2009.  Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen.. Cancer Biol Ther. 8(13):1212-3.

Tang X-H, Vivero M, Gudas LJ.  2008.  Overexpression of CRABPI in suprabasal keratinocytes enhances the proliferation of epidermal basal keratinocytes in mouse skin topically treated with all-trans retinoic acid.. Exp Cell Res. 314(1):38-51.

Zhuang Y, Gudas LJ.  2008.  Overexpression of COUP-TF1 in murine embryonic stem cells reduces retinoic acid-associated growth arrest and increases extraembryonic endoderm gene expression.. Differentiation. 76(7):760-71.

Tang X-H, Knudsen B, Bemis D, Tickoo S, Gudas LJ.  2004.  Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice.. Clin Cancer Res. 10(1 Pt 1):301-13.

Liu L, Tang X-H, Scognamiglio T, Gudas LJ.  2010.  Oral carcinogenesis induced by 4-nitroquinoline 1-oxide in lecithin:retinol acyltransferase gene knockout mice.. J Nutr Biochem. 21(10):975-82.

Simandi Z, Horvath A, Wright LC, Cuaranta-Monroy I, De Luca I, Karolyi K, Sauer S, Deleuze J-F, Gudas LJ, Cowley SM et al..  2016.  OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation.. Mol Cell. 63(4):647-661.

Trasino SE, Tang X-H, Jessurun J, Gudas LJ.  2015.  Obesity Leads to Tissue, but not Serum Vitamin A Deficiency.. Sci Rep. 5:15893.

van der Mijn JC, Laursen KB, Fu L, Khani F, Dow LE, Nowak DG, Chen Q, Gross SS, Nanus DM, Gudas LJ.  2023.  Novel genetically engineered mouse models for clear cell renal cell carcinoma.. Sci Rep. 13(1):8246.

Kubala JM, Laursen KB, Schreiner R, Williams RM, van der Mijn JC, Crowley MJ, Mongan NP, Nanus DM, Heller DA, Gudas LJ.  2023.  NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.. Cancer Biol Ther. 24(1):2170669.

Molina AM, van der Mijn JC, Christos P, Wright J, Thomas C, Dutcher JP, Nanus DM, Tagawa ST, Gudas LJ.  2020.  NCI 6896: a phase I trial of vorinostat (SAHA) and isotretinoin (13-cis retinoic acid) in the treatment of patients with advanced renal cell carcinoma.. Invest New Drugs.

Trasino SE, Tang X-H, Trujillo C, Andres J, Ehrt S, Gudas LJ.  2020.  Mycobacterium tuberculosis infection is exacerbated in mice lacking lecithin:retinol acyltransferase.. Biochim Biophys Acta Mol Basis Dis. 1866(11):165909.