Submitted by aii2002 on April 5, 2020 - 3:25pm
| Title | Crossing the barrier: STRA6 in epidermal differentiation. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Laursen KB, Gudas LJ |
| Journal | J Invest Dermatol |
| Volume | 134 |
| Issue | 6 |
| Pagination | 1504-1506 |
| Date Published | 2014 Jun |
| ISSN | 1523-1747 |
| Keywords | Animals, Epidermis, Gene Expression Regulation, Humans, Keratinocytes, Membrane Proteins |
| Abstract | In this issue, Skazik et al. demonstrate that the STRA6 retinol transporter protein regulates the proliferation and differentiation of epidermal keratinocytes. In human organotypic three-dimensional skin and skin reconstitution models, depletion of STRA6 induced hyperproliferation-associated differentiation, resulting in epidermal expansion. This reveals that STRA6 functions as a "gatekeeper" in retinol (vitamin A)-mediated differentiation of human skin. |
| DOI | 10.1038/jid.2014.49 |
| Alternate Journal | J. Invest. Dermatol. |
| PubMed ID | 24825059 |