Submitted by aii2002 on April 5, 2020 - 3:25pm
Title | The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Urvalek A, Laursen KBruun, Gudas LJ |
Journal | Subcell Biochem |
Volume | 70 |
Pagination | 129-49 |
Date Published | 2014 |
ISSN | 0306-0225 |
Keywords | Chromatin, Chromatin Assembly and Disassembly, DNA Methylation, Epigenesis, Genetic, Histones, Humans, Neoplasms, Protein Binding, Protein Multimerization, Protein Processing, Post-Translational, Receptors, Retinoic Acid, Retinoid X Receptors, RNA, Untranslated, Signal Transduction, Tretinoin |
Abstract | Epigenetics is "the branch of biology which studies the causal interactions between genes and their products which bring the phenotype into being" as defined by Conrad Waddington in 1942 in a discussion of the mechanisms of cell differentiation. More than seven decades later we know that these mechanisms include histone tail post-translational modifications, DNA methylation, ATP-dependent chromatin remodeling, and non-coding RNA pathways. Epigenetic modifications are powerful drugs targets, and combined targeting of multiple pathways is expected to significantly advance cancer therapy. |
DOI | 10.1007/978-94-017-9050-5_7 |
Alternate Journal | Subcell. Biochem. |
PubMed ID | 24962884 |
PubMed Central ID | PMC4199334 |
Grant List | R01-CA043796 / CA / NCI NIH HHS / United States T32 CA062948 / CA / NCI NIH HHS / United States R01 AA018332 / AA / NIAAA NIH HHS / United States R01-DE010389 / DE / NIDCR NIH HHS / United States F32-AA021045 / AA / NIAAA NIH HHS / United States F32 AA021045 / AA / NIAAA NIH HHS / United States R01 CA043796 / CA / NCI NIH HHS / United States R01 DE010389 / DE / NIDCR NIH HHS / United States |