Publications

Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Metzler VM, Persson JL, Robinson BD, Khani F, Alsaleem M, Ntekim A et al..  2022.  The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.. Cancers (Basel). 14(20)

Laursen KB, Kashyap V, Scandura J, Gudas LJ.  2015.  An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency.. J Biol Chem. 290(7):4356-66.

Quintero CM, Laursen KB, Mongan NP, Luo M, Gudas LJ.  2018.  CARM1 (PRMT4) Acts as a Transcriptional Coactivator during Retinoic Acid-Induced Embryonic Stem Cell Differentiation.. J Mol Biol. 430(21):4168-4182.

Hedblom A, Laursen KB, Miftakhova R, Sarwar M, Anagnostaki L, Bredberg A, Mongan NP, Gudas LJ, Persson JL.  2013.  CDK1 interacts with RARγ and plays an important role in treatment response of acute myeloid leukemia.. Cell Cycle. 12(8):1251-66.

Laursen KB, Gudas LJ.  2018.  Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.. J Biol Chem. 293(30):11891-11900.

Laursen KB, Gudas LJ.  2014.  Crossing the barrier: STRA6 in epidermal differentiation.. J Invest Dermatol. 134(6):1504-1506.

Laursen KB, Wong P-M, Gudas LJ.  2012.  Epigenetic regulation by RARα maintains ligand-independent transcriptional activity.. Nucleic Acids Res. 40(1):102-15.

Serio RN, Laursen KB, Urvalek AM, Gross SS, Gudas LJ.  2019.  Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ.. J Biol Chem. 294(14):5536-5548.

Benoit YD, Laursen KB, Witherspoon MS, Lipkin SM, Gudas LJ.  2013.  Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.. J Cell Physiol. 228(4):764-72.

Metzler VM, de Brot S, Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Nilsson EM, Ntekim A, Persson JL, Robinson BD et al..  2023.  The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.. Front Cell Dev Biol. 11:1116424.

Nilsson EM, Laursen KB, Whitchurch J, McWilliam A, Ødum N, Persson JL, Heery DM, Gudas LJ, Mongan NP.  2015.  MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.. Oncotarget. 6(34):35710-25.

Laursen KB, Chen Q, Khani F, Attarwala N, Gross SS, Dow L, Nanus DM, Gudas LJ.  2021.  Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma.. Front Oncol. 11:783856.

Kubala JM, Laursen KB, Schreiner R, Williams RM, van der Mijn JC, Crowley MJ, Mongan NP, Nanus DM, Heller DA, Gudas LJ.  2023.  NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.. Cancer Biol Ther. 24(1):2170669.

van der Mijn JC, Laursen KB, Fu L, Khani F, Dow LE, Nowak DG, Chen Q, Gross SS, Nanus DM, Gudas LJ.  2023.  Novel genetically engineered mouse models for clear cell renal cell carcinoma.. Sci Rep. 13(1):8246.

Benoit YD, Witherspoon MS, Laursen KB, Guezguez A, Beauséjour M, Beaulieu J-F, Lipkin SM, Gudas LJ.  2013.  Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells.. Exp Cell Res. 319(10):1463-70.

Laursen KB, Mongan NP, Zhuang Y, Ng MM, Benoit YD, Gudas LJ.  2013.  Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene.. Nucleic Acids Res. 41(13):6430-43.

Kashyap V, Laursen KB, Brenet F, Viale AJ, Scandura JM, Gudas LJ.  2013.  RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells.. J Cell Sci. 126(Pt 4):999-1008.

van der Mijn JC, Chen Q, Laursen KB, Khani F, Wang X, Dorsaint P, Sboner A, Gross SS, Nanus DM, Gudas LJ.  2022.  Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR).. Mol Carcinog.

Benjamin DN, O'Donovan TR, Laursen KB, Orfali N, Cahill MR, Mongan NP, Gudas LJ, McKenna SL.  2022.  All-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism.. Front Oncol. 12:848517.